Anti-IQSEC2 Antibody Picoband®

This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

E.coli-derived human IQSEC2 recombinant protein (Position: A122-M1396) . Human IQSEC2 shares 98.2% amino acid (aa) sequence identity with mouse IQSEC2.

1. de Vries, B. B. A., Breedveld, G. J., Deelen, W. H., Niermeijer, M. F., Heutink, P., Breuning, M. H. Another family with nonspecific X-linked mental retardation (MRX78) maps to Xp11.4-p11.23. Am. J. Med. Genet. 111: 443-445, 2002. Note: Erratum: Am. J. Med. Genet. 113: 391 only 2002. 2. Filippova, G. N., Cheng, M. K., Moore, J. M., Truong, J.-P., Hu, Y. J., Nguyen, D. K., Tsuchiya, K. D., Disteche, C. M. Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Dev. Cell 8: 31-42, 2005. 3. Gedeon, A., Kerr, B., Mulley, J., Turner, G. Pericentromeric genes for non-specific X-linked mental retardation (MRX) . Am. J. Med. Genet. 51: 553-564, 1994.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.