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Anti-NEUROG3 Antibody Picoband® Biotin Conjugated

Product Specifications

Background

The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4) .

Synonyms

NEUROG3; ATOH5; BHLHA7; NGN3; Neurogenin-3; NGN-3; Class A basic helix-loop-helix protein 7; bHLHa7; Protein atonal homolog 5

Gene Name

NEUROG3

Gene ID

50674

UniProt

Q9Y4Z2

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human NEUROG3 recombinant protein (Position: Q137-L214) . Human NEUROG3 shares 72.2% amino acid (aa) sequence identity with mouse NEUROG3.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Gradwohl, G., Dierich, A., LeMeur, M., Guillemot, F. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Nat. Acad. Sci. 97: 1607-1611, 2000. 2. Kim, S.-H., Warram, J. H., Krolewski, A. S., Doria, A. Mutation screening of the neurogenin-3 gene in autosomal dominant diabetes. J. Clin. Endocr. Metab. 86: 2320-2322, 2001. 3. Lee, C. S., Perreault, N., Brestelli, J. E., Kaestner, K. H. Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev. 16: 1488-1497, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

23 kDa

Gene Name Synonym

Neurogenin 3

Protein Name

Neurogenin-3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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