Anti-IA-2/PTPRN Antibody Picoband® APC Conjugated

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.

PTPRN; ICA3; ICA512; Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2 [Cleaved into: ICA512-N-terminal fragment; ICA512-NTF; ICA512-transmembrane fragment; ICA512-TMF; ICA512-cleaved cytosolic fragment; ICA512-CCF]

E.coli-derived human IA-2/PTPRN recombinant protein (Position: V35-H569) . Human IA-2/PTPRN shares 79.5% amino acid (aa) sequence identity with rat IA-2/PTPRN.

1. Lan, M. S., Lu, J., Goto, Y., Notkins, A. L. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol. 13: 505-514, 1994. 2. Leiter, E. H., Tsumura, H., Serreze, D. V., Chapman, H. D., Rabin, D. U., Lan, M. S., Notkins, A. L. Mapping to chromosomes 1 and 12 of mouse homologs of human protein tyrosine phosphatase, receptor-type, related genes encoding pancreatic beta cell autoantigens. Mammalian Genome 8: 949-950, 1997. 3. Morahan, G., Huang, D., Yu, W.-P., Cui, L., DeAizpurua, H., Pallen, C. J. Localization of the genes encoding the type I diabetes autoantigens, protein-tyrosine phosphatases IA2 and IAR. Mammalian Genome 9: 593-594, 1998.