Anti-POLD4 Antibody Picoband® APC Conjugated
Product Specifications
Background
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms
POLD4; POLDS; DNA polymerase delta subunit 4; DNA polymerase delta subunit p12
Gene Name
POLD4
Gene ID
57804
UniProt
Q9HCU8
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human POLD4 recombinant protein (Position: M1-L107) . Human POLD4 shares 83.2% amino acid (aa) sequence identity with mouse POLD4.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Gross, M. B. Personal Communication. Baltimore, Md. 4/9/2018. 2. Liu, G., Warbrick, E. The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins. Biochem. Biophys. Res. Commun. 349: 360-366, 2006. 3. Liu, L., Mo, J., Rodriguez-Belmonte, E. M., Lee, M. Y. W. T. Identification of a fourth subunit of mammalian DNA polymerase delta. J. Biol. Chem. 275: 18739-18744, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
12 kDa
Applications Notes
6
Gene Name Synonym
DNA polymerase delta 4, accessory subunit
Protein Name
DNA polymerase delta subunit 4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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