Anti-POLD4 Antibody Picoband® HRP Conjugated
Product Specifications
Background
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms
POLD4; POLDS; DNA polymerase delta subunit 4; DNA polymerase delta subunit p12
Gene Name
POLD4
Gene ID
57804
UniProt
Q9HCU8
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human POLD4 recombinant protein (Position: M1-L107) . Human POLD4 shares 83.2% amino acid (aa) sequence identity with mouse POLD4.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Gross, M. B. Personal Communication. Baltimore, Md. 4/9/2018. 2. Liu, G., Warbrick, E. The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins. Biochem. Biophys. Res. Commun. 349: 360-366, 2006. 3. Liu, L., Mo, J., Rodriguez-Belmonte, E. M., Lee, M. Y. W. T. Identification of a fourth subunit of mammalian DNA polymerase delta. J. Biol. Chem. 275: 18739-18744, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
12 kDa
Gene Name Synonym
DNA polymerase delta 4, accessory subunit
Protein Name
DNA polymerase delta subunit 4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.
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