Anti-POLR1E Antibody Picoband® APC Conjugated

Predicted to enable DNA binding activity and RNA polymerase I general transcription initiation factor binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I and transcription initiation at RNA polymerase I promoter. Located in fibrillar center and nucleoplasm. Part of RNA polymerase I complex.

POLR1E; PAF53; PRAF1; DNA-directed RNA polymerase I subunit RPA49; RNA polymerase I subunit A49; DNA-directed RNA polymerase I subunit E; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53

1. Hanada, K., Song, C. Z., Yamamoto, K., Yano, K., Maeda, Y., Yamaguchi, K., Muramatsu, M. RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. EMBO J. 15: 2217-2226, 1996. 2. Kong, R., Zhang, L., Hu, L., Peng, Q., Han, W., Du, X., Ke, Y. hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF) . J. Biol. Chem. 286: 7139-7148, 2011. 3. McNamar, R., Abu-Adas, Z., Rothblum, K., Knutson, B. A., Rothblum, L. I. Conditional depletion of the RNA polymerase I subunit PAF53 reveals that it is essential for mitosis and enables identification of functional domains. J. Biol. Chem. 294: 19907-19922, 2019.