Anti-OSCAR Antibody Picoband®

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

OSCAR; Osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; hOSCAR; Polymeric immunoglobulin receptor 3; PIgR-3; PIgR3; Poly-Ig receptor 3

1. Barrow, A. D., Palarasah, Y., Bugatti, M., Holehouse, A. S., Byers, D. E., Holtzman, M. J., Vermi, W., Skjodt, K., Crouch, E., Colonna, M. OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes. J. Immun. 194: 3317-3326, 2015. 2. Kim, K., Kim, J. H., Lee, J., Jin, H.-M., Lee, S.-H., Fisher, D. E., Kook, H., Kim, K. K., Choi, Y., Kim, N. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. J. Biol. Chem. 280: 35209-35216, 2005. 3. Kim, N., Takami, M., Rho, J., Josien, R., Choi, Y. A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J. Exp. Med. 195: 201-209, 2002.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.