Anti-STAMBP Antibody Picoband® Biotin Conjugated
Product Specifications
Background
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Synonyms
STAMBP; AMSH; STAM-binding protein; EC 3.4.19.-; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase
Gene Name
STAMBP
Gene ID
10617
UniProt
O95630
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human STAMBP recombinant protein (Position: K187-R424) . Human STAMBP shares 79% and 79.8% amino acid (aa) sequence identity with mouse and rat STAMBP, respectively.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Carter, M. T., Geraghty, M. T., De La Cruz, L., Reichard, R. R., Boccuto, L., Schwartz, C. E., Clericuzio, C. L. A new syndrome with multiple capillary malformations, intractable seizures, and brain and limb anomalies. Am. J. Med. Genet. 155A: 301-306, 2011. 2. Ishii, N., Owada, Y., Yamada, M., Miura, S., Murata, K., Asao, H., Kondo, H., Sugamura, K. Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice. Molec. Cell. Biol. 21: 8626-8637, 2001. 3. Isidor, B., Barbarot, S., Beneteau, C., Le Caignec, C., David, A. Multiple capillary skin malformations, epilepsy, microcephaly, mental retardation, hypoplasia of the distal phalanges: report of a new case and further delineation of a new syndrome. (Letter) Am. J. Med. Genet. 155A: 1458-1460, 2011.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
48 kDa
Gene Name Synonym
STAM binding protein
Protein Name
STAM-binding protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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