Anti-TOX3 Antibody Picoband® HRP Conjugated

The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.

TOX3; CAGF9; TNRC9; TOX high mobility group box family member 3; CAG trinucleotide repeat-containing gene F9 protein; Trinucleotide repeat-containing gene 9 protein

E.coli-derived human TOX3 recombinant protein (Position: M1-Q560) . Human TOX3 shares 95% and 95.2% amino acid (aa) sequence identity with mouse and rat TOX3, respectively.

1. Antoniou, A. C., Spurdle, A. B., Sinilnikova, O. M., Healey, S., Pooley, K. A., Schmutzler, R. K., Versmold, B., Engel, C., Meindl, A., Arnold, N., Hofmann, W., Sutter, C., and 80 others. Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am. J. Hum. Genet. 82: 937-948, 2008. 2. Cowper-Sal-lari, R., Zhang, X., Wright, J. B., Bailey, S. D., Cole, M. D., Eeckhoute, J., Moore, J. H., Lupien, M. Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression. Nature Genet. 44: 1191-1198, 2012. 3. O'Flaherty, E., Kaye, J. TOX defines a conserved subfamily of HMG-box proteins. BMC Genomics 4: 13, 2003. Note: Electronic Article.