Anti-PICK1 Antibody Picoband® APC Conjugated

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA) . This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.

E.coli-derived human PICK1 recombinant protein (Position: A41-E376) . Human PICK1 shares 97.3% and 99.4% amino acid (aa) sequence identity with mouse and rat PICK1, respectively.

1. Boudin, H., Doan, A., Xia, J., Shigemoto, R., Huganir, R. L., Worley, P., Craig, A. M. Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron 28: 485-497, 2000. 2. Cowan, C. A., Yokoyama, N., Bianchi, L. M., Henkemeyer, M., Fritzsch, B. EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron 26: 417-430, 2000. 3. Dev, K. K., Nishimune, A., Henley, J. M., Nakanishi, S. The protein kinase C-alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits. Neuropharmacology 38: 635-644, 1999.