Anti-MINPP1 Antibody Picoband® HRP Conjugated

His gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.

MINPP1; MIPP; UNQ900/PRO1917; Multiple inositol polyphosphate phosphatase 1; EC 3.1.3.62; 2,3-bisphosphoglycerate 3-phosphatase; 2,3-BPG phosphatase; EC 3.1.3.80; Inositol; 1,3,4,5-tetrakisphosphate 3-phosphatase; Ins (1,3,4,5P (4 3-phosphatase

E.coli-derived human MINPP1 recombinant protein (Position: R155-H421) . Human MINPP1 shares 89.5% and 89.9% amino acid (aa) sequence identity with mouse and rat MINPP1, respectively.

1. Appelhof, B., Wagner, M., Hoefele, J., Heinze, A., Roser, T., Koch-Hogrebe, M., Roosendaal, S. D., Dehghani, M., Mehrjardi, M. Y. V., Torti, E., Houlden, H., Maroofian, R., Rajabi, F., Sticht, H., Baas, F., Wieczorek, D., Jamra, R. A. Pontocerebellar hypoplasia due to bi-allelic variants in MINPP1. Europ. J. Hum. Genet. 29: 411-421, 2021. 2. Caffrey, J. J., Hidaka, K., Matsuda, M., Hirata, M., Shears, S. B. The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification. FEBS Lett. 442: 99-104, 1999. 3. Chi, H., Tiller, G. E., Dasouki, M. J., Romano, P. R., Wang, J., O'Keefe, R. J., Puzas, J. E., Rosier, R. N., Reynolds, P. R. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. Genomics 56: 324-336, 1999.