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Anti-DNAJB6 Antibody Picoband® HRP Conjugated

Product Specifications

Background

This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.

Synonyms

DNAJB6; HSJ2; MRJ; MSJ1; DnaJ homolog subfamily B member 6; HHDJ1; Heat shock protein J2; HSJ-2; MRJ; MSJ-1

Gene Name

DNAJB6

Gene ID

10049

UniProt

O75190

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human DNAJB6.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Bengoechea, R., Pittman, S. K., Tuck, E. P., True, H. L., Weihl, C. C. Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D. Hum. Molec. Genet. 24: 6588-6602, 2015. 2. Chuang, J.-Z., Zhou, H., Zhu, M., Li, S.-H., Li, X.-J., Sung, C.-H. Characterization of a brain-enriched chaperone, MRJ, that inhibits huntingtin aggregation and toxicity independently. J. Biol. Chem. 277: 19831-19838, 2002. 3. Couthouis, J., Raphael, A. R., Siskind, C., Findlay, A. R., Buenrostro, J. D., Greenleaf, W. J., Vogel, H., Day, J. W., Flanigan, K. M., Gitler, A. D. Exome sequencing identifies a DNAJB6 mutation in a family with dominantly-inherited limb-girdle muscular dystrophy. Neuromusc. Disord. 24: 431-435, 2014.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

36 kDa

Gene Name Synonym

DnaJ heat shock protein family (Hsp40) member B6

Protein Name

DnaJ homolog subfamily B member 6

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.

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