Anti-C14orf166/RTRAF Antibody Picoband® Biotin Conjugated

Enables RNA binding activity; RNA polymerase II complex binding activity; and identical protein binding activity. Involved in negative regulation of protein kinase activity; positive regulation of transcription by RNA polymerase II; and tRNA splicing, via endonucleolytic cleavage and ligation. Located in microtubule cytoskeleton; nucleoplasm; and perinuclear region of cytoplasm. Part of tRNA-splicing ligase complex.

E.coli-derived human C14orf166/RTRAF recombinant protein (Position: M1-R244) . Human C14orf166/RTRAF shares 97.1% amino acid (aa) sequence identity with mouse C14orf166/RTRAF.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 12/18/2014. 2. Howng, S.-L., Hsu, H.-C., Cheng, T.-S., Lee, Y.-L., Chang, L.-K., Lu, P.-J., Hong, Y.-R. A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3-beta and is highly expressed in brain tumors. FEBS Lett. 566: 162-168, 2004. 3. Huarte, M., Sanz-Ezquerro, J. J., Roncal, F., Ortin, J., Nieto, A. PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. J. Virol. 75: 8597-8604, 2001.