Anti-GARNL1/RALGAPA1 Antibody Picoband® HRP Conjugated

This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9.

RALGAPA1; GARNL1; KIAA0884; TULIP1; Ral GTPase-activating protein subunit alpha-1; GAP-related-interacting partner to E12; GRIPE; GTPase-activating Rap/Ran-GAP domain-like 1; Tuberin-like protein 1; p240

E.coli-derived human GARNL1/RALGAPA1 recombinant protein (Position: S503-H1729) . Human GARNL1/RALGAPA1 shares 95% amino acid (aa) sequence identity with both mouse and rat GARNL1/RALGAPA1.

1. Heng, J. I. T., Tan, S.-S. Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain. J. Biol. Chem. 277: 43152-43159, 2002. 2. Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5: 277-286, 1998. 3. Schwarzbraun, T., Vincent, J. B., Schumacher, A., Geschwind, D. H., Oliveira, J., Windpassinger, C., Ofner, L., Ledinegg, M. K., Kroisel, P. M., Wagner, K., Petek, E. Cloning, genomic structure, and expression profiles of TULIP1 (GARNL1), a brain-expressed candidate gene for 14q13-linked neurological phenotypes, and its murine homologue. Genomics 84: 577-586, 2004.