Anti-NUDT18 Antibody Picoband® APC Conjugated

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates.

NUDT18; MTH3; 8-oxo-dGDP phosphatase NUDT18; EC 3.6.1.58; 2-hydroxy-dADP phosphatase; 7,8-dihydro-8-oxoguanine phosphatase; MutT homolog 3; Nucleoside diphosphate-linked moiety X motif 18; Nudix motif 18

E.coli-derived human NUDT18 recombinant protein (Position: M1-R291) . Human NUDT18 shares 82.8% and 83.2% amino acid (aa) sequence identity with mouse and rat NUDT18, respectively.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 5/13/2014. 2. Takagi, Y., Setoyama, D., Ito, R., Kamiya, H., Yamagata, Y., Sekiguchi, M. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. J. Biol. Chem. 287: 21541-21549, 2012.