Anti-NCOA6 Antibody Picoband® HRP Conjugated

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

NCOA6; AIB3; KIAA0181; RAP250; TRBP; Nuclear receptor coactivator 6; Activating signal cointegrator 2; ASC-2; Amplified in breast cancer protein 3; Cancer-amplified transcriptional coactivator ASC-2; Nuclear receptor coactivator RAP250; NRC RAP250; Nuclear receptor-activating protein, 250 kDa; Peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; Thyroid hormone receptor-binding protein

1. Antonson, P., Jakobsson, T., Almlof, T., Guldevall, K., Steffensen, K. R., Gustafsson, J.-A. RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. J. Biol. Chem. 283: 8995-9001, 2008. 2. Antonson, P., Schuster, G. U., Wang, L., Rozell, B., Holter, E., Flodby, P., Treuter, E., Holmgren, L., Gustafsson, J.-A. Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Molec. Cell. Biol. 23: 1260-1268, 2003. 3. Caira, F., Antonson, P., Pelto-Huikko, M., Treuter, E., Gustafsson, J.-A. Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J. Biol. Chem. 275: 5308-5317, 2000.