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Anti-POLR1A Antibody Picoband® Biotin Conjugated

Product Specifications

Background

DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene. The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis.

Synonyms

POLR1A; DNA-directed RNA polymerase I subunit RPA1; RNA polymerase I subunit A1; EC 2.7.7.6; A190; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; RNA polymerase I 194 kDa subunit; RPA194

Gene Name

POLR1A

Gene ID

25885

UniProt

O95602

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human POLR1A recombinant protein (Position: E607-R1720) . Human POLR1A shares 86.3% and 87.3% amino acid (aa) sequence identity with mouse and rat POLR1A, respectively.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. da Rocha, L. A., Pires, L. V. L., Yamamoto, G. L., Magliocco Ceroni, J. R., Honjo, R. S., de Novaes Franca Bisneto, E., Oliveira, L. A. N., Rosenberg, C., Krepischi, A. C. V., Passos-Bueno, M. R., Kim, C. A., Bertola, D. R. Congenital limb deficiency: genetic investigation of 44 individuals presenting mainly longitudinal defects in isolated or syndromic forms. Clin. Genet. 100: 615-623, 2021. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 6/2/2015. 3. Kara, B., Koroglu, C., Peltonen, K., Steinberg, R., Maras Genc, H., Holtta-Vuori, M., Guven, A., Kanerva, K., Kotil, T., Solakoglu, S., Zhou, Y., Olkkonen, V. M., Ikonen, E., Laiho, M., Tolun, A. Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A. Europ. J. Hum. Genet. 25: 315-323, 2017.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

195 kDa

Gene Name Synonym

RNA polymerase I subunit A

Protein Name

DNA-directed RNA polymerase I subunit RPA1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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