Anti-REM2 Antibody Picoband® Biotin Conjugated

Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be involved in negative regulation of high voltage-gated calcium channel activity. Predicted to be active in plasma membrane.

E.coli-derived human REM2 recombinant protein (Position: R65-E257) . Human REM2 shares 94.8% and 95.9% amino acid (aa) sequence identity with mouse and rat REM2, respectively.

1. Bierings, R., Beato, M., Edel, M. J. An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19 (ARF) expression that promotes endothelial cell proliferation and angiogenesis. J. Biol. Chem. 283: 4408-4416, 2008. 2. Edel, M. J., Menchon, C., Menendez, S., Consiglio, A., Raya, A., Belmonte, J. C. I. Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. Genes Dev. 24: 561-573, 2010. 3. Finlin, B. S., Shao, H., Kadono-Okuda, K., Guo, N., Andres, D. A. Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. Biochem. J. 347: 223-231, 2000.