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Anti-CEP135 Antibody Picoband® APC Conjugated

Product Specifications

Background

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene. This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8.

Synonyms

CEP135; CEP4; KIAA0635; Centrosomal protein of 135 kDa; Cep135; Centrosomal protein 4

Gene Name

CEP135

Gene ID

9662

UniProt

Q66GS9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CEP135 recombinant protein (Position: E28-E1034) . Human CEP135 shares 82.8% amino acid (aa) sequence identity with mouse CEP135.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P., Nigg, E. A., Mann, M. Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426: 570-574, 2003. 2. Carvalho-Santos, Z., Machado, P., Branco, P., Tavares-Cadete, F., Rodrigues-Martins, A., Pereira-Leal, J. B., Bettencourt-Dias, M. Stepwise evolution of the centriole-assembly pathway. J. Cell Sci. 123: 1414-1426, 2010. 3. Farooq, M., Fatima, A., Mang, Y., Hansen, L., Kjaer, K. W., Baig, S. M., Larsen, L. A., Tommerup, N. A novel splice site mutation in CEP135 is associated with primary microcephaly in a Pakistani family. J. Hum. Genet. 61: 271-273, 2016.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

133 kDa

Applications Notes

6

Gene Name Synonym

Centrosomal protein 135

Protein Name

Centrosomal protein of 135 kDa

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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