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Anti-CEP135 Antibody Picoband® HRP Conjugated

Product Specifications

Background

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene. This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8.

Synonyms

CEP135; CEP4; KIAA0635; Centrosomal protein of 135 kDa; Cep135; Centrosomal protein 4

Gene Name

CEP135

Gene ID

9662

UniProt

Q66GS9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CEP135 recombinant protein (Position: E28-E1034) . Human CEP135 shares 82.8% amino acid (aa) sequence identity with mouse CEP135.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P., Nigg, E. A., Mann, M. Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426: 570-574, 2003. 2. Carvalho-Santos, Z., Machado, P., Branco, P., Tavares-Cadete, F., Rodrigues-Martins, A., Pereira-Leal, J. B., Bettencourt-Dias, M. Stepwise evolution of the centriole-assembly pathway. J. Cell Sci. 123: 1414-1426, 2010. 3. Farooq, M., Fatima, A., Mang, Y., Hansen, L., Kjaer, K. W., Baig, S. M., Larsen, L. A., Tommerup, N. A novel splice site mutation in CEP135 is associated with primary microcephaly in a Pakistani family. J. Hum. Genet. 61: 271-273, 2016.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

133 kDa

Gene Name Synonym

Centrosomal protein 135

Protein Name

Centrosomal protein of 135 kDa

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.

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