Anti-CDKN2AIP/CARF Antibody Picoband® Cy3 Conjugated

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of DNA-binding transcription factor activity. Located in granular component. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and skeletal muscle tissue. Orthologous to human CARF (calcium responsive transcription factor) .

Carf; Als2cr8; Calcium-responsive transcription factor; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; Calcium-response factor; CaRF

E.coli-derived mouse CDKN2AIP/CARF recombinant protein (Position: R183-T689) . Human CDKN2AIP/CARF shares 78.3% and 88.1% amino acid (aa) sequence identity with human and rat CDKN2AIP/CARF, respectively.

1. Tao, X., West, A. E., Chen, W. G., Corfas, G., Greenberg, M. E. A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron 33: 383-395, 2002.