Anti-Calpain 6/CAPN6 Antibody Picoband® Biotin Conjugated

Calpain-6 (also known as calpamodulin) is a protein in humans that is encoded by the CAPN6 gene. Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.

E.coli-derived human Calpain 6/CAPN6 recombinant protein (Position: M1-L641) . Human Calpain 6/CAPN6 shares 95.2% and 95% amino acid (aa) sequence identity with mouse and rat Calpain 6/CAPN6, respectively.

1. Dear, N., Matena, K., Vingron, M., Boehm, T. A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Genomics 45: 175-184, 1997. 2. Matena, K., Boehm, T., Dear, T. N. Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily. Genomics 48: 117-120, 1998.