Anti-CYP4F2 Antibody Picoband® APC Conjugated

Cytochrome P450 4F2 is a protein that in humans is encoded by the CYP4F2 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.

CYP4F2; Cytochrome P450 4F2; EC 1.14.14.1; 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; Arachidonic acid omega-hydroxylase; CYPIVF2; Cytochrome P450-LTB-omega; Docosahexaenoic acid omega-hydroxylase; EC 1.14.14.79; Leukotriene-B (4 20-monooxygenase 1; Leukotriene-B (4 omega-hydroxylase 1; EC 1.14.14.94; Phylloquinone omega-hydroxylase CYP4F2; EC 1.14.14.78

1. Caldwell, M. D., Awad, T., Johnson, J. A., Gage, B. F., Falkowski, M., Gardina, P., Hubbard, J., Turpaz, Y., Langaee, T. Y., Eby, C., King, C. R., Brower, A., Schmelzer, J. R., Glurich, I., Vidaillet, H. J., Yale, S. H., Zhang, K. Q., Berg, R. L., Bumester, J. K. CYP4F2 genetic variant alters required warfarin dose. Blood 111: 4106-4112, 2008. 2. Kikuta, Y., Miyauchi, Y., Kusunose, E., Kusunose, M. Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene. DNA Cell Biol. 18: 723-730, 1999. 3. Ross, K. A., Bigham, A. W., Edwards, M., Gozdzik, A., Suarez-Kurtz, G., Parra, E. J. Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements. J. Hum. Genet. 55: 582-589, 2010.