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Anti-CYP4F2 Antibody Picoband® HRP Conjugated

Product Specifications

Background

Cytochrome P450 4F2 is a protein that in humans is encoded by the CYP4F2 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.

Synonyms

CYP4F2; Cytochrome P450 4F2; EC 1.14.14.1; 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; Arachidonic acid omega-hydroxylase; CYPIVF2; Cytochrome P450-LTB-omega; Docosahexaenoic acid omega-hydroxylase; EC 1.14.14.79; Leukotriene-B (4 20-monooxygenase 1; Leukotriene-B (4 omega-hydroxylase 1; EC 1.14.14.94; Phylloquinone omega-hydroxylase CYP4F2; EC 1.14.14.78

Gene Name

CYP4F2

Gene ID

8529

UniProt

P78329

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human CYP4F2.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Caldwell, M. D., Awad, T., Johnson, J. A., Gage, B. F., Falkowski, M., Gardina, P., Hubbard, J., Turpaz, Y., Langaee, T. Y., Eby, C., King, C. R., Brower, A., Schmelzer, J. R., Glurich, I., Vidaillet, H. J., Yale, S. H., Zhang, K. Q., Berg, R. L., Bumester, J. K. CYP4F2 genetic variant alters required warfarin dose. Blood 111: 4106-4112, 2008. 2. Kikuta, Y., Miyauchi, Y., Kusunose, E., Kusunose, M. Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene. DNA Cell Biol. 18: 723-730, 1999. 3. Ross, K. A., Bigham, A. W., Edwards, M., Gozdzik, A., Suarez-Kurtz, G., Parra, E. J. Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements. J. Hum. Genet. 55: 582-589, 2010.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

60 kDa

Gene Name Synonym

Cytochrome P450 family 4 subfamily F member 2

Protein Name

Cytochrome P450 4F2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.

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