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Anti-CTNNBL1 Antibody Picoband® Biotin Conjugated

Product Specifications

Background

Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene. The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome.

Synonyms

CTNNBL1; C20orf33; PP8304; Beta-catenin-like protein 1; Nuclear-associated protein; NAP; Testis development protein NYD-SP19

Gene Name

CTNNBL1

Gene ID

56259

UniProt

Q8WYA6

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CTNNBL1 recombinant protein (Position: Q122-E231) . Human CTNNBL1 shares 97.3% and 98.2% amino acid (aa) sequence identity with mouse and rat CTNNBL1, respectively.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Conticello, S. G., Ganesh, K., Xue, K., Lu, M., Rada, C., Neuberger, M. S. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Molec. Cell 31: 474-484, 2008. 2. Ganesh, K., Adam, S., Taylor, B., Simpson, P., Rada, C., Neuberger, M. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. J. Biol. Chem. 286: 17091-17102, 2011. 3. Jabbour, L., Welter, J. F., Kollar, J., Hering, T. M. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Genomics 81: 292-303, 2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

65 kDa

Gene Name Synonym

Catenin beta like 1

Protein Name

Beta-catenin-like protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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