Anti-NSMAF Antibody Picoband® APC Conjugated

This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.

1. Adam-Klages, S., Adam, D., Wiegmann, K., Struve, S., Kolanus, W., Schneider-Mergener, J., Kronke, M. FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Cell 86: 937-947, 1996. 2. Montfort, A., de Badts, B., Douin-Echinard, V., Martin, P. G. P., Iacovoni, J., Nevoit, C., Therville, N., Garcia, V., Bertrand, M.-A., Bessieres, M.-H., Trombe, M.-C., Levade, T., Benoist, H., Segui, B. FAN stimulates TNF-alpha-induced gene expression, leukocyte recruitment, and humoral response. J. Immun. 183: 5369-5378, 2009. 3. Segui, B., Cuvillier, O., Adam-Klages, S., Garcia, V., Malagarie-Cazenave, S., Leveque, S., Caspar-Bauguil, S., Coudert, J., Salvayre, R., Kronke, M., Levade, T. Involvement of FAN in TNF-induced apoptosis. J. Clin. Invest. 108: 143-151, 2001.