Anti-CEP110/CNTRL Antibody Picoband® FITC Conjugated

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110. This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1.

1. Guasch, G., Mack, G. J., Popovici, C., Dastugue, N., Birnbaum, D., Rattner, J. B., Pebusque, M.-J. FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t (8;9) (p12; q33) . Blood 95: 1788-1796, 2000. 2. Ou, Y. Y., Mack, G. J., Zhang, M., Rattner, J. B. CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. J. Cell Sci. 115: 1825-1835, 2002. 3. Popovici, C., Mattei, M.-G., Rattner, J. B., Birnbaum, D., Pebusque, M.-J. Assignment of the centrosomal protein 110 gene (Cep110) to mouse chromosome bands 2B-C1 by in situ hybridization. Cytogenet. Cell Genet. 89: 216-217, 2000.