Anti-OTUD6B Antibody Picoband®

OTU domain containing 6B is a protein that in humans is encoded by the OTUD6B gene. This gene encodes a member of the ovarian tumor domain (OTU) -containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells.

1. Kayagaki, N., Phung, Q., Chan, S., Chaudhari, R., Quan, C., O'Rourke, K. M., Eby, M., Pietras, E., Cheng, G., Bazan, J. F., Zhang, Z., Arnott, D., Dixit, V. M. DUBA: a deubiquitinase that regulates type I interferon production. Science 318: 1628-1632, 2007. 2. Santiago-Sim, T., Burrage, L. C., Ebstein, F., Tokita, M. J., Miller, M., Bi, W., Braxton, A. A., Rosenfeld, J. A., Shahrour, M., Lehmann, A., Cogne, B., Kury, S., and 33 others. Biallelic variants in OTUD6B cause an intellectual disability syndrome associated with seizures and dysmorphic features. Am. J. Hum. Genet. 100: 676-688, 2017. 3. Sobol, A., Askonas, C., Alani, S., Weber, M. J., Ananthanarayanan, V., Osipo, C., Bocchetta, M. Deubiquitinase OTUD6B isoforms are important regulators of growth and proliferation. Molec. Cancer Res. 15: 117-127, 2017.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.