Anti-MCM9 Antibody Picoband® Fluoro647 Conjugated

The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1.

MCM9; C6orf61; MCMDC1; DNA helicase MCM9; hMCM9; EC 3.6.4.12; Mini-chromosome maintenance deficient domain-containing protein 1; Minichromosome maintenance 9

E.coli-derived human MCM9 recombinant protein (Position: M1-L644) . Human MCM9 shares 92.7% and 93% amino acid (aa) sequence identity with mouse and rat MCM9, respectively.

1. Fauchereau, F., Shalev, S., Chervinsky, E., Beck-Fruchter, R., Legois, B., Fellous, M., Caburet, S., Veitia, R. A. A non-sense MCM9 mutation in a familial case of primary ovarian insufficiency. Clin. Genet. 89: 603-607, 2016. 2. Lutzmann, M., Grey, C., Traver, S., Ganier, O., Maya-Mendoza, A., Ranisavljevic, N., Bernex, F., Nishiyama, A., Montel, N., Gavois, E., Forichon, L., de Massy, B., Mechali, M. MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination. Molec. Cell 47: 523-534, 2012. 3. Lutzmann, M., Maiorano, D., Mechali, M. Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family. Gene 362: 51-56, 2005.