Anti-Renin receptor/ATP6AP2 Antibody Picoband®

The renin receptor also known as ATPase H (+) -transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene. This gene encodes a protein that is associated with adenosine triphosphatases (ATPases) . Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases.

ATP6AP2; ATP6IP2; CAPER; ELDF10; HT028; MSTP009; PSEC0072; Renin receptor; ATPase H (+-transporting lysosomal accessory protein 2; ATPase H (+-transporting lysosomal-interacting protein 2; ER-localized type I transmembrane adaptor; Embryonic liver differentiation factor 10; N14F; Renin/prorenin receptor; Vacuolar ATP synthase membrane sector-associated protein M8-9; ATP6M8-9; V-ATPase M8.9 subunit [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment]

A synthetic peptide corresponding to a sequence at the C-terminus of human Renin receptor/ATP6AP2, which shares 100% and 95.8% amino acid (aa) sequence identity with mouse and rat Renin receptor/ATP6AP2, respectively.

1. Cruciat, C.-M., Ohkawara, B., Acebron, S. P., Karaulanov, E., Reinhard, C., Ingelfinger, D., Boutros, M., Niehrs, C. Requirement of prorenin receptor and vacuolar H (+) -ATPase-mediated acidification for Wnt signaling. Science 327: 459-463, 2010. 2. Demirci, F. Y. K., White, N. J., Rigatti, B. W., Lewis, K. F., Gorin, M. B. Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4) . Molec. Vis. 7: 234-239, 2001. Note: Electronic Article. 3. Dubos, A., Castells-Nobau, A., Meziane, H., Oortveld, M. A. W., Houbaert, X., Iacono, G., Martin, C., Mittelhaeuser, C., Lalanne, V., Kramer, J. M., Bhukel, A., Quentin, C., and 10 others. Conditional deletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration. Hum. Molec. Genet. 24: 6736-6755, 2015.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.