Anti-Myosin Light Chain 2/MLC-2V/MYL2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. This gene encodes a major sarcomeric protein in mammalian striated muscle. The encoded protein plays a role in embryonic heart muscle structure and function, while phosphorylation of the encoded protein is involved in cardiac myosin cycling kinetics, torsion and function in adults. Mutations in this gene are associated with hypertrophic cardiomyopathy 10 and infant-onset myopathy.
Synonyms
MYL2; MLC2; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2; MLC-2v; Cardiac myosin light chain 2; Myosin light chain 2, slow skeletal/ventricular muscle isoform; MLC-2s/v; Ventricular myosin light chain 2
Gene Name
MYL2
Gene ID
4633
UniProt
P10916
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Myosin Light Chain 2/MLC-2V/MYL2, which shares 95.7% amino acid (aa) sequence identity with both mouse and rat Myosin Light Chain 2/MLC-2V/MYL2.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Barth, P. G., Wanders, R. J. A., Ruitenbeek, W., Roe, C., Scholte, H. R., van der Harten, H., van Moorsel, J., Duran, M., Dingemans, K. P. Infantile fibre type disproportion, myofibrillar lysis and cardiomyopathy: a disorder in three unrelated Dutch families. Neuromusc. Disord. 8: 296-304, 1998. 2. Davis, J. S., Hassanzadeh, S., Winitsky, S., Lin, H., Satorius, C., Vemuri, R., Aletras, A. H., Wen, H., Epstein, N. D. The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation. Cell 107: 631-641, 2001. 3. Flavigny, J., Richard, P., Isnard, R., Carrier, L., Charron, P., Bonne, G., Forissier, J.-F., Desnos, M., Dubourg, O., Komajda, M., Schwartz, K., Hainque, B. Identification of two novel mutations in the ventricular regulatory myosin light chain gene (MYL2) associated with familial and classical forms of hypertrophic cardiomyopathy. J. Molec. Med. 76: 208-214, 1998.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A03215-3-Fluoro647
Calculated Molecular Weight
19 kDa
Applications Notes
6
Gene Name Synonym
Myosin light chain 2
Protein Name
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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