Anti-Biglycan/BGN Antibody Picoband®

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication.

1. Camera, G., Stella, G., Camera, A. New X linked spondyloepimetaphyseal dysplasia: report on eight affected males in the same family. J. Med. Genet. 31: 371-376, 1994. 2. Chatterjee, A., Faust, C. J., Herman, G. E. Genetic and physical mapping of the biglycan gene on the mouse X chromosome. Mammalian Genome 4: 33-36, 1993. 3. Cho, S. Y., Bae, J.-S., Kim, N. K. D., Forzano, F., Girisha, K. M., Baldo, C., Faravelli, F., Cho, T.-J., Kim, D., Lee, K. Y., Ikegawa, S., Shim, J. S., Ko, A.-R., Miyake, N., Nishimura, G., Superti-Furga, A., Spranger, J., Kim, O.-H., Park, W.-Y., Jin, D.-K. BGN mutations in X-linked spondyloepimetaphyseal dysplasia. Am. J. Hum. Genet. 98: 1243-1248, 2016.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.