Anti-LZTS2 Antibody Picoband®

The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants.

E.coli-derived human LZTS2 recombinant protein (Position: M1-I669) . Human LZTS2 shares 91.7% and 90.5% amino acid (aa) sequence identity with mouse and rat LZTS2, respectively.

1. Cabeza-Arvelaiz, Y., Thompson, T. C., Sepulveda, J. L., Chinault, A. C. LAPSER1: a novel candidate tumor suppressor gene from 10q24.3. Oncogene 20: 6707-6717, 2001. 2. Nagase, T., Nakayama, M., Nakajima, D., Kikuno, R., Ohara, O. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 8: 85-95, 2001. 3. Peng, Y., Clark, C., Luong, R., Tu, W. H., Lee, J., Johnson, D. T., Das, A. Carroll, T. J., Sun, Z. The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development. J. Biol. Chem. 286: 40331-40342, 2011.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.