Anti-ATP6V1B2 Antibody Picoband®

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.

1. Abo-Dalo, B., Roes, M., Canun, S., Delatycki, M., Gillessen-Kaesbach, G., Hrytsiuk, I., Jung, C., Kerr, B., Mowat, D., Seemanova, E., Steiner, C. E., Stewart, H., Thierry, P., van Buggenhout, G., White, S., Zenker, M., Kutsche, K. No mutation in genes of the WNT signaling pathway in patients with Zimmermann-Laband syndrome. Clin. Dysmorph. 17: 181-185, 2008. 2. Bernasconi, P., Rausch, T., Struve, I., Morgan, L., Taiz, L. An mRNA from human brain encodes an isoform of the B subunit of the vacuolar H (+) -ATPase. J. Biol. Chem. 265: 17428-17431, 1990. 3. Castori, M., Valiante, M., Pascolini, G., Leuzzi, V., Pizzuti, A., Grammatico, P. Clinical and genetic study of two patients with Zimmermann-Laband syndrome and literature review. Europ. J. Med. Genet. 56: 570-576, 2013.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.