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Anti-NGEF Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; ephrin receptor signaling pathway; and negative regulation of dendritic spine morphogenesis. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse.

Gene Name

NGEF

Gene ID

25791

UniProt

Q8N5V2

Host

Rabbit

Reactivity

Human

Immunogen

E.coli-derived human NGEF recombinant protein (Position: E82-Q627) . Human NGEF shares 91.1% and 90.9% amino acid (aa) sequence identity with mouse and rat NGEF, respectively.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Frank, C. A., Pielage, J., Davis, G. W. A presynaptic homeostatic signaling system composed of the Eph receptor, Ephexin, Cdc42, and Cav2.1 calcium channels. Neuron 61: 556-569, 2009. 2. Rodrigues, N. R., Theodosiou, A. M., Nesbit, M. A., Campbell, L., Tandle, A. T., Saranath, D., Davies, K. E. Characterization of Ngef, a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus. Genomics 65: 53-61, 2000. 3. Shamah, S. M., Lin, M. Z., Goldberg, J. L., Estrach, S., Sahin, M., Hu, L., Bazalakova, M., Neve, R. L., Corfas, G., Debant, A., Greenberg, M. E. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 105: 233-244, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

82,71 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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