Anti-NGEF Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; ephrin receptor signaling pathway; and negative regulation of dendritic spine morphogenesis. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse.
Gene Name
NGEF
Gene ID
25791
UniProt
Q8N5V2
Host
Rabbit
Reactivity
Human
Immunogen
E.coli-derived human NGEF recombinant protein (Position: E82-Q627) . Human NGEF shares 91.1% and 90.9% amino acid (aa) sequence identity with mouse and rat NGEF, respectively.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Frank, C. A., Pielage, J., Davis, G. W. A presynaptic homeostatic signaling system composed of the Eph receptor, Ephexin, Cdc42, and Cav2.1 calcium channels. Neuron 61: 556-569, 2009. 2. Rodrigues, N. R., Theodosiou, A. M., Nesbit, M. A., Campbell, L., Tandle, A. T., Saranath, D., Davies, K. E. Characterization of Ngef, a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus. Genomics 65: 53-61, 2000. 3. Shamah, S. M., Lin, M. Z., Goldberg, J. L., Estrach, S., Sahin, M., Hu, L., Bazalakova, M., Neve, R. L., Corfas, G., Debant, A., Greenberg, M. E. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 105: 233-244, 2001.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
82,71 kDa
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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