Anti-NCLN Antibody Picoband® Fluoro550 Conjugated

Nicalin is a protein that in humans is encoded by the NCLN gene. Enables ribosome binding activity. Involved in protein stabilization; regulation of protein complex stability; and regulation of protein-containing complex assembly. Located in endoplasmic reticulum membrane. Part of protein-containing complex.

E.coli-derived human NCLN recombinant protein (Position: Q59-Q563) . Human NCLN shares 92.9% and 92.5% amino acid (aa) sequence identity with mouse and rat NCLN, respectively.

1. Dettmer, U., Kuhn, P.-H., Abou-Ajram, C., Lichtenthaler, S. F., Kruger, M., Kremmer, E., Haass, C., Haffner, C. Transmembrane protein 147 (TMEM147) is a novel component of the nicalin-NOMO protein complex. J. Biol. Chem. 285: 26174-26181, 2010. 2. Haffner, C., Frauli, M., Topp, S., Irmler, M., Hofmann, K., Regula, J. T., Bally-Cuif, L., Haass, C. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. EMBO J. 23: 3041-3050, 2004. 3. Stumpf, A. M. Personal Communication. Baltimore, Md. 08/17/2021.