Anti-GBP1 Antibody Picoband® Fluoro647 Conjugated

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene. It belongs to the dynamin superfamily of large GTPases. Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.

1. Cheng, Y.-S. E., Patterson, C. E., Staeheli, P. Interferon-induced guanylate-binding proteins lack an N (T) KXD consensus motif and bind GMP in addition to GDP and GTP. Molec. Cell. Biol. 11: 4717-4725, 1991. 2. Gaudet, R. G., Zhu, S., Halder, A., Kim, B.-H., Bradfield, C. J., Huang, S., Xu, D., Maminska, A., Nguyen, T. N., Lazarou, M., Karatekin, E., Gupta, K., MacMicking, J. D. A human apolipoprotein L with detergent-like activity kills intracellular pathogens. Science 373: eabf8113, 2021. 3. Ghosh, A., Praefcke, G. J. K., Renault, L., Wittinghofer, A., Herrmann, C. How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Nature 440: 101-104, 2006.