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Anti-GBP1 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene. It belongs to the dynamin superfamily of large GTPases. Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.

Gene Name

GBP1

Gene ID

2633

UniProt

P32455

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human GBP1 recombinant protein (Position: E190-S592) .

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Cheng, Y.-S. E., Patterson, C. E., Staeheli, P. Interferon-induced guanylate-binding proteins lack an N (T) KXD consensus motif and bind GMP in addition to GDP and GTP. Molec. Cell. Biol. 11: 4717-4725, 1991. 2. Gaudet, R. G., Zhu, S., Halder, A., Kim, B.-H., Bradfield, C. J., Huang, S., Xu, D., Maminska, A., Nguyen, T. N., Lazarou, M., Karatekin, E., Gupta, K., MacMicking, J. D. A human apolipoprotein L with detergent-like activity kills intracellular pathogens. Science 373: eabf8113, 2021. 3. Ghosh, A., Praefcke, G. J. K., Renault, L., Wittinghofer, A., Herrmann, C. How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Nature 440: 101-104, 2006.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

68 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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