Anti-GBF1 Antibody Picoband®

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene. This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene.

1. Mansour, S. J., Herbrick, J.-A., Scherer, S. W., Melancon, P. Human GBF1 is a ubiquitously expressed gene of the Sec7 domain family mapping to 10q24. Genomics 54: 323-327, 1998. 2. Mendoza-Ferreira, N., Karakaya, M., Cengiz, N., Beijer, D., Brigatti, K. W., Gonzaga-Jauregui, C., Fuhrmann, N., Holker, I., Thelen, M. P., Zetzsche, S., Rombo, R., Puffenberger, E. G., and 9 others. De novo and inherited variants in GBF1 are associated with axonal neuropathy caused by golgi fragmentation. Am. J. Hum. Genet. 107: 763-777, 2020. 3. Nagase, T., Seki, N., Ishikawa, K., Ohira, M., Kawarabayasi, Y., Ohara, O., Tanaka, A., Kotani, H., Miyajima, N., Nomura, N. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 3: 321-329, 1996.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.