Anti-MAGI2 Antibody Picoband® Fluoro647 Conjugated

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene. The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.

E.coli-derived human MAGI2 recombinant protein (Position: Q40-P1140) . Human MAGI2 shares 97.5% and 96.8% amino acid (aa) sequence identity with mouse and rat MAGI2, respectively.

1. Balbas, M. D., Burgess, M. R., Murali, R., Wongvipat, J., Skaggs, B. J., Mundel, P., Weins, A., Sawyers, C. L. MAFI-2 scaffold protein is critical for kidney barrier function. Proc. Nat. Acad. Sci. 111: 14876-14881, 2014. 2. Bauss, K., Knapp, B., Jores, P., Roepman, R., Kremer, H., v. Wijk, E., Marker, T., Wolfrum, U. Phosphorylation of the Usher syndrome 1G protein SANS controls Magi2-mediated endocytosis. Hum. Molec. Genet. 23: 3923-3942, 2014. 3. Bierzynska, A., Soderquest, K., Dean, P., Colby, E., Rollason, R., Jones, C., Inward, C. D., McCarthy, H. J., Simpson, M. A., Lord, G. M., Williams, M., Welsh, G. I., Koziell, A. B., Saleem, M. A., NephrosS, the UK study of Nephrotic Syndrome. MAGI2 mutations cause congenital nephrotic syndrome. J. Am. Soc. Nephrol. 28: 1614-1621, 2017.