Anti-MARVELD2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
MARVEL domain-containing protein 2 is a protein that in humans is encoded by the MARVELD2 gene. The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49) . Two transcript variants encoding different isoforms have been found for this gene.
Gene Name
MARVELD2
Gene ID
153562
UniProt
Q8N4S9
Host
Rabbit
Reactivity
Human, Rat
Immunogen
E.coli-derived human MARVELD2 recombinant protein (Position: R12-H496) . Human MARVELD2 shares 87% amino acid (aa) sequence identity with mouse MARVELD2.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Chishti, M. S., Bhatti, A., Tamim, S., Lee, K., McDonald, M.-L., Leal, S. M., Ahmad, W. Splice-site mutations in the TRIC gene underlie autosomal recessive nonsyndromic hearing impairment in Pakistani families. J. Hum. Genet. 53: 101-105, 2008. 2. Ikenouchi, J., Furuse, M., Furuse, K., Sasaki, H., Tsukita, S., Tsukita, S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J. Cell Biol. 171: 939-945, 2005. 3. Riazuddin, S., Ahmed, Z. M., Fanning, A. S., Lagziel, A., Kitajiri, S., Ramzan, K., Khan, S. N., Chattaraj, P., Friedman, P. L., Anderson, J. M., Belyantseva, I. A., Forge, A., Riazuddin, S., Friedman, T. B. Tricellulin is a tight-junction protein necessary for hearing. Am. J. Hum. Genet. 79: 1040-1051, 2006.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
64 kDa
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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