Anti-GANAB Antibody Picoband® Fluoro488 Conjugated

Neutral alpha-glucosidase AB is an enzyme that in humans is encoded by the GANAB gene. This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease.

1. Besse, W., Choi, J., Ahram, D., Mane, S., Sanna-Cherchi, S., Torres, V., Somlo, S. A noncoding variant in GANAB explains isolated polycystic liver disease (PCLD) in a large family. Hum. Mutat. 39: 378-382, 2018. 2. Martiniuk, F., Smith, M., Desnick, R., Astrin, K., Mitra, J., Hirschhorn, R. Assignment of the gene for neutral alpha-glucosidase AB to chromosome 11. (Abstract) Am. J. Hum. Genet. 34: 173A only, 1982. 3. Martiniuk, F., Smith, M., Ellenbogen, A., Desnick, R. J., Astrin, K., Mitra, J., Hirschhorn, R. Assignment of the gene for neutral alpha-glucosidase AB to chromosome 11. Cytogenet. Cell Genet. 35: 110-116, 1983.