Anti-BCL6 Antibody Picoband® Fluoro488 Conjugated

Bcl-6 (B-cell lymphoma 6) is a protein that in humans is encoded by the BCL6 gene. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

1. Akasaka, T., Miura, I., Takahashi, N., Akasaka, H., Yonetani, N., Ohno, H., Fukuhara, S., Okuma, M. A recurring translocation, t (3;6) (q27; p21), in non-Hodgkin's lymphoma results in replacement of the 5-prime regulatory region of BCL6 with a novel H4 histone gene. Cancer Res. 57: 7-12, 1997. 2. Barnett, B. E., Ciocca, M. L., Goenka, R., Barnett, L. G., Wu, J., Laufer, T. M., Burkhardt, J. K., Cancro, M. P., Reiner, S. L. Asymmetric B cell division in the germinal center reaction. Science 335: 342-344, 2012. 3. Baron, B. W., Nucifora, G., McCabe, N., Espinosa, R., III, Le Beau, M. M., McKeithan, T. W. Identification of the gene associated with the recurring chromosomal translocations t (3;14) (q27; q32) and t (3;22) (q27; q11) in B-cell lymphomas. Proc. Nat. Acad. Sci. 90: 5262-5266, 1993.