Anti-NAXE Antibody Picoband®

Apolipoprotein A-I-binding protein also known as APOA1BP is a protein that in humans is encoded by the APOA1BP gene. The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs) . It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes.

E.coli-derived human NAXE recombinant protein (Position: R46-Q288) . Human NAXE shares 93% and 94.2% amino acid (aa) sequence identity with mouse and rat NAXE, respectively.

1. Fang, L., Choi, S.-H., Baek, J. S., Liu, C., Almazan, F., Ulrich, F., Wiesner, P., Taleb, A., Deer, E., Pattison, J., Torres-Vazquez, J., Li, A. C., Miller, Y. I. Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature 498: 118-122, 2013. 2. Kremer, L. S., Danhauser, K., Herebian, D., Ramadza, D. P., Piekutowska-Abramczuk, D., Seibt, A., Muller-Felber, W., Haack T. B., Ploski, R., Lohmeier, K., Schneider, D., Klee, D., and 10 others. NAXE mutations disrupt the cellular NAD (P) HX repair system and cause a lethal neurometabolic disorder of early childhood. Am. J. Hum. Genet. 99: 894-902, 2016. 3. Marbaix, A. Y., Tyteca, D., Niehaus, T. D., Hanson, A. D., Linster, C. L., Van Schaftingen, E. Occurrence and subcellular distribution of the NAD (P) HX repair system in mammals. Biochem. J. 460: 49-58, 2014.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.