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Anti-DVL2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene. This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

Gene Name

DVL2

Gene ID

132299

UniProt

O14641

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human DVL2 recombinant protein (Position: L89-Y576) . Human DVL2 shares 97.3% amino acid (aa) sequence identity with mouse DVL2.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Capelluto, D. G. S., Kutateladze, T. G., Habas, R., Finkielstein, C. V., He, X., Overduin, M. The DIX domain targets dishevelled to actin stress fibres and vesicular membranes. Nature 419: 726-729, 2002. 2. Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L. A., Miller, W. E., Caron, M. G., Barak, L. S., Nusse, R., Lefkowitz, R. J. Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of frizzled 4. Science 301: 1391-1394, 2003. 3. Greco, T. L., Sussman, D. J., Camper, S. A. Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11. Mammalian Genome 7: 475-476, 1996.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

79 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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