Anti-POC1A Antibody Picoband® Fluoro647 Conjugated

POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutations in this gene result in short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) syndrome.

1. Hames, R. S., Hames, R., Prosser, S. L., Euteneuer, U., Lopes, C. A. M., Moore, W., Woodland, H. R., Fry, A. M. Pix1 and Pix2 are novel WD40 microtubule-associated proteins that colocalize with mitochondria in Xenopus germ plasm and centrosomes in human cells. Exp. Cell Res. 314: 574-589, 2008. 2. Keller, L. C., Geimer, S., Romijn, E., Yates, J., III, Zamora, I., Marshall, W. F. Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control. Molec. Biol. Cell 20: 1150-1166, 2009. 3. Sarig, O., Nahum, S., Rapaport, D., Ishida-Yamamoto, A., Fuchs-Telem, D., Qiaoli, L., Cohen-Katsenelson, K., Spiegel, R., Nousbeck, J., Israeli, S., Borochowitz, Z.-U., Padalon-Brauch, G., Uitto, J., Horowitz, M., Shalev, S., Sprecher, E. Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis syndrome is caused by a POC1A mutation. Am. J. Hum. Genet. 91: 337-342, 2012.