Anti-RS1 Antibody Picoband® Fluoro550 Conjugated

Retinoschisin also known as X-linked juvenile retinoschisis protein is a lectin that in humans is encoded by the RS1 gene. This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision.

1. Byrne, J., Warburton, D. Male excess among anatomically normal fetuses in spontaneous abortions. Am. J. Med. Genet. 26: 605-611, 1987. 2. Eriksson, A. W., Vainio-Mattila, B., Krause, U., Fellman, J., Forsius, H. Secondary sex ratio in families with X-chromosomal disorders. Hereditas 57: 373-381, 1967. 3. Gehrig, A., Weber, B. H. F., Lorenz, B., Andrassi, M. First molecular evidence for a de novo mutation in RS1 (XLRS1) associated with X-linked juvenile retinoschisis. J. Med. Genet. 36: 932-934, 1999.