Anti-RS1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Retinoschisin also known as X-linked juvenile retinoschisis protein is a lectin that in humans is encoded by the RS1 gene. This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision.
Gene Name
RS1
Gene ID
6247
UniProt
O15537
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
E.coli-derived human RS1 recombinant protein (Position: Y34-A224) . Human RS1 shares 96.9% amino acid (aa) sequence identity with mouse RS1.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Byrne, J., Warburton, D. Male excess among anatomically normal fetuses in spontaneous abortions. Am. J. Med. Genet. 26: 605-611, 1987. 2. Eriksson, A. W., Vainio-Mattila, B., Krause, U., Fellman, J., Forsius, H. Secondary sex ratio in families with X-chromosomal disorders. Hereditas 57: 373-381, 1967. 3. Gehrig, A., Weber, B. H. F., Lorenz, B., Andrassi, M. First molecular evidence for a de novo mutation in RS1 (XLRS1) associated with X-linked juvenile retinoschisis. J. Med. Genet. 36: 932-934, 1999.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
25 kDa
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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