Anti-S100P Antibody Picoband® Fluoro550 Conjugated

S100 calcium-binding protein P (S100P) is a protein that in humans is encoded by the S100P gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer.

1. Becker, T., Gerke, V., Kube, E., Weber, K. S100P, a novel Ca (2+) -binding protein from human placenta: cDNA cloning, recombinant protein expression and Ca (2+) binding properties. Europ. J. Biochem. 207: 541-547, 1992. 2. Dowen, S. E., Crnogorac-Jurcevic, T., Gangeswaran, R., Hansen, M., Eloranta, J. J., Bhatka, V., Brentnall, T. A., Luttges, J., Kloppel, G., Lemoine, N. R. Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. Am. J. Path. 166: 81-92, 2005. 3. Schafer, B. W., Wicki, R., Engelkamp, D., Mattei, M.-G., Heizmann, C. W. Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Genomics 25: 638-643, 1995.